For me spread gun because of its versatility, coverage, and ease of use, especially in chaotic levels. Its ability to hit enemies from multiple angles often makes it a lifesaver.
I always have good results using the Laser. The big thing about it for me is the piercing power that it has. When I am fighting against bosses and enemies that are heavily protected by armors, it really helps me to do extensive damage. I know that the downside of using it is that you would lose a little coverage but it is what I find my way around.